Download e-book for kindle: Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall

By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the most typical toxicological objective within the endocrine procedure, the adrenal gland has frequently been missed in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations on hand to envision adrenal endocrine disruption.

Examining present strategies and the most recent developments, Adrenal Toxicology experiences the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers details at the variety of substances and chemical substances that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro evaluate. This quantity additionally provides contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the most important advancements revamped the previous decade
  • focuses at the most modern study recommendations, together with their makes use of and limitations
  • provides an built-in method for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, delivering impetus for regulatory consideration

Show description

By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the most typical toxicological objective within the endocrine procedure, the adrenal gland has frequently been missed in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations on hand to envision adrenal endocrine disruption.

Examining present strategies and the most recent developments, Adrenal Toxicology experiences the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article offers details at the variety of substances and chemical substances that have an effect on adrenocortical functionality and indicates standardized methods for in vivo and in vitro evaluate. This quantity additionally provides contemporary advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the most important advancements revamped the previous decade
  • focuses at the most modern study recommendations, together with their makes use of and limitations
  • provides an built-in method for adrenal toxicology evaluation
  • identifies wisdom and knowledge gaps, delivering impetus for regulatory consideration

Show description

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Extra resources for Adrenal Toxicology

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London: Taylor & Francis; 1996:223—242. Baos R, Blas J, Bortolotti GR, et al. Adrenocortical response to stress and thyroid status in free-living nestling white storks (Ciconia ciconia) exposed to heavy metal and arsenic contamination. Environ Health Perspect 2006; 114:1497–1501. Barrett AM. Some factors affecting blood ACTH levels. Acta Endocrinol 1960; 51:421. Billaudel B, Sutter BCJ. Immediate in vivo effects of corticosterone on glucose induced insulin secretion in rats. J Endocrinol 1982; 95:315–320.

Adrenal morphology and hormone synthesis and regulation. In: Harvey PW, ed. The Adrenal in Toxicology: Target Organ and Modulator of Toxicity. London: Taylor & Francis, 1996:23–52. Hinson JP, Raven PW. Adrenal Toxicology. In: Harvey PW, Rush KC, Cockburn A, eds. Endocrine and Hormonal Toxicology. Chichester: John Wiley, 1999:67–89. Hinson JP, Raven PW. Effects of endocrine-disrupting chemicals on adrenal function. Best Practice and Research Clinical Endocrinology and Metabolism 2006; 20:111– 120.

Adrenocortical Hyperstimulation and Excess: Persistent Developmental Consequences Although pituitary-adrenal hyperactivity through direct or indirect stress related mechanisms is considered a much less serious toxicological finding in regulatory toxicology studies compared with frank adrenal suppression, pituitaryadrenocortical overactivity nevertheless can also be detrimental (see discussion on Cushing’s syndrome), particularly developmentally. , 1976; Skebelskaya, 1968). , 2006). , 2005 for neuroendocrine-immune interactions specifically involving the HPA axis in immunotoxicology).

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall


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