By Alan Ebringer
Ankylosing spondylitis and Klebsiella is a accomplished and informative textual content at the explanation for Ankylosing spondylitis. Ankylosing spondylitis (AS) is a which impacts 20 million humans around the globe and is probably going prompted or initiated by way of a bowel an infection from Klebsiella bacteria.
When a sufferer is contaminated by means of Klebsiella bacteria, his or her immune method will make antibodies opposed to the entire antigens or molecules present in the microbe. simply because many of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but in addition the self tissues reminiscent of the joints and the cells having an analogous HLA molecules, that is how the affliction AS begins. this can be the concept that of molecular similarity or “molecular mimicry” which formerly has been stumbled on to paintings in different autoimmune ailments; rheumatic fever and rheumatoid arthritis.
The first paper in this topic used to be released in 1976 and because thenover a hundred papers on rheumatological themes were released, from Prof Ebringer’s team, on the department of existence Sciences, King’s university in London, united kingdom.
The appropriate details from those papers is extracted and provided during this publication layout making it available to well-being pros, examine associations, pharmaceutical businesses and universities and most of the people.
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Additional resources for Ankylosing spondylitis and Klebsiella
1968;57:1–7. Léri A. Études sur les affections de la colonne vertébrale. Paris: Masson; 1926. Rogers J, Watt I, Dieppe P. Paleopathology of spinal osteophytosis, vertebral ankylosis, ankylosing spondylitis and vertebral hyperostosis. Ann Rheum Dis. 1985;44:113–20. Schilder DP, Harvey WP, Hufnagel CA. Rheumatoid spondylitis and and aortic insuffciency. N Engl J Med. 1956;255:358–61. Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A. Ankylosing spondylitis: an overview. Ann Rheum Dis. 2002;61(Suppl III):iii8–18.
Frank Dudley Hart and asked him for some information on HLA and rheumatism. ” Thereupon I contacted his registrar Dr. Roger Sturrock who duly sent an assortment of blood specimens taken at random from rheumatic patients. Not surprisingly, the HLA results showed no predominant feature and were very disappointing to us. The fact that the two samples from ankylosing spondylitis patients had HLA-B27 held no message for us at the time. I next remember mentioning my quest for a disease having a familial tendency with a rheumatological background to my colleague Professor John Hobbs, who immediately remarked “Why not have a word with Dr.
5 Bacterial Agglutination Enterobacter aerogenes microorganisms, cultured as described previously, were adjusted to Brown Opacity 4 and stored at 4 °C. S. 60 × 7 mm), incubated at 37 °C for 4 h and overnight at 4 °C. Tubes 26 4 Molecular Mimicry Between HLA-B27 and Klebsiella Bacteria were examined under diffuse light, compared to bacterial suspension without added serum and the highest antiserum dilution resulting in visible agglutination recorded as the end point. 3 × 1013 microorganisms) and ultrasonicated.
Ankylosing spondylitis and Klebsiella by Alan Ebringer